朱晓玥
教授
博士生导师、硕士生导师
联系地址：
福建农林大学海峡联合研究院 福州 350002
Email: xiaoyuezhu@fafu.edu.cn
学习及工作经历：
2016至今 福建农林大学，教授
2013-2016 东华大学， 副教授
2006-2013 美国 Incept BioSystems, Inc.，工程师
2005-2006 美国University of Michigan - Ann Arbor，博士后
2002-2005 美国University of Michigan - Ann Arbor，博士
成果：
1成功建立了一套以纳米材料及微流控芯片为基础的研究细胞功能和生长发育的全新实验方法和体系
2 研制开发了一系列细胞特异性的微流控芯片及纳米材料, 获得美国授权专利四项
研究方向：
通过研发各种新型植物及动物细胞培养平台，对园艺作物发育及代谢组产物进行功能性研究。在细胞和组织层面，通过将纳米技术及细胞生物学技术相结合的全新方法，进一步探索细胞生长和发育的分子机理。
发表文章：
[1] Wang MY, Tan YL, Li D, Xu GW, Yin D, Xiao YC, Xu TG, Chen XF*, Zhu XY*, Shi XY*. Negative isolation of circulating tumor cells using a microfluidic platform integrated with streptavidin-functionalized PLGA nanofibers. Advanced Fiber materials, 2021,3 (3), p192-202 (DOI：10.1007/s42765-021-00075-x)
[2] Zhou X, Lu J, Zhang YQ, Guo JZ, Lin WW, Van Norman JM, Qin Y, Zhu XY, Yang ZB*. Membrane receptor-mediated mechano-transduction maintains cell integrity during pollen tube growth within the pistil. Developmental Cell, 2021, 56(7), p1030+
[3] Gao SY, Wu L, Xu TG, Zhu XY, Wang XF, Chen JZ, Zhou W, Li XX*. A soft casting PDMS process using multifunctional cover for fabrication of precise microfluidic chips. 2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers).
[4] Lin WW, Zhou X, Tang WX, Takahashi K, Pan X, Dai JW, Ren H, Zhu XY, Pan SQ, Zheng HY, Gray WM, Xu TD, Kinoshita T, Yang ZB*. TMK-based cell-surface auxin signaling activates cell-wall acidification. Nature, 2021, 599: 278-282
[5] Xu TG, Wu L, Wang XF, Zhu XY, Chen JZ, Yao FL, Zhou HB, Li XX*. A seal-free valveless digital PCR chip supported with a high-pressure water circulation system. Proceedings IEEE Micro Electro Mechanical Systems, 2020, 1079-1082 (Proceedings paper, 2020 33rd IEEE International Conference on Micro Electro Mechanical Systems)
[6] Xu TG, Wu L, Wang XF, Zhu XY, Bao YG, Cai SR, Li G, Li XX*. A PDMS-Based Digital PCR Chip with Vacuum Aspiration and Water-filling Cavity Integrated for Sample Loading and Evaporation Reduction. Proceedings IEEE Micro Electro Mechanical Systems, 2018, 1142-1145 (Proceedings paper, 2018 IEEE Micro Electro Mechanical Systems)
[7] Wu L, Xu TG, Li G, Zhu XY, Zhao JL*. A Facile Alignment of PDMS Layers for the Fabrication of 3D Microfluidic Devices Using Synergistic Zipper. Proceedings IEEE Micro Electro Mechanical Systems 2018, 1265-1268 (Proceedings paper, 2018 IEEE Micro Electro Mechanical Systems)
[8] Wang MY, Xiao YC, Lin LZ, Zhu XY, Du LF, Shi XY*. A microfluidic chip integrated with hyaluronic acid-functionalized electrospun chitosan nanofibers for specific capture and nondestructive release of CD44-overexpressing circulating Tumor Cells. Bioconjugate Chemistry, 2018, 1081-1090 DOI: 10.1021/acs.bioconjchem.7b00747
[9] Xu GW, Tan YL, Xu TG, Yin D, Wang MY, Shen MW, Chen XF*, Shi XY*, Zhu XY*. Hyaluronic acid-functionalized electrospun PLGA nanofibers embedded in a microfluidic chip for cancer cell capture and culture. Biomaterial Sciences, 2017, 5, 752-761
[10] Yin D, Xu GW, Wang MY, Shen MW, Xu TG, Zhu XY*, Shi XY*. Effective cell trapping using PDMS microspheres in an acoustofluidic chip. Colloids Surf., B 2017, 157, 347-354
[11] Kim SJ, Zhu XY, Takayama S. Gravity-driven fluid pumping and cell manipulation. Microtechnology for Cell Manipulation and Sorting, Springer science + business media, 2017, 175-192
[12] Fan ZY, Zhao YL, Zhu XY*, Luo Y, Shen MW, Shi XY*. Folic acid-modified electrospun polyvinyl alcohol/polyethyleneimine nanofibers for cancer cell capture applications. Chin. J. Polym. Sci. 2016, 34, 755 - 765. doi:10.1007/s10118-016-1792-6
[13] Zhou BQ, Yang J, Peng C, Zhu JZ, Tang YQ, Zhu XY, Shen MW, Zhang GX*, Shi XY*. PEGylated polyethylenimine-entrapped gold nanoparticles modified with folic acid for targeted tumor CT imaging. Colloids and Surfaces B. Biointerfaces, 2016:140:489-496. DOI: 10.1016/j.colsurfb.2016.01.019
[14] Li D, Zhang YX, Wen SH, Song Y, Tang YQ, Zhu XY, Shen MW, Mignani S, Majoral JP, Zhao QH*, Shi XY*. Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy. J. Mater. Chem. B 2016, 4, 4216 -4226
[15] Chen C, Zhou BQ, Zhu XY, Shen MW, Shi XY*. Branched polyethyleneimine modified with hyaluronic acid via a PEG spacer for targeted anticancer drug delivery. RSC Adv. 2016, 6, 9232 - 9239
[16] Zhao YL, Zhu XY, Liu H, Luo Y, Wang SG, Shen MW, Zhu MF, Shi XY*. Dendrimer-functionalized electrospun cellulose acetate nanofibers for targeted cancer cell capture applications. J. Mater. Chem. B 2014, 2, 7384–7393.
[17] Moracs C, Kim BC, Zhu XY, Mills K, Dixon AR, Thouless MD, Takayama S*, Defined topologically-complex protein matrices to manipulate cell shape via three-dimensional fiber-like patterns, Lab-on-a-chip, DOI:10.1039/C4LC00122B, 2014
[18] Mills KL, Zhu XY, Takayama S, Thouless MD*, The mechanical properties of a surfacemodified layer on poly(dimethylsiloxane), Journal of Materials Research, 2008,23: 37-48
[19] Huh D, Mills KL, Zhu XY, Burns MA, Thouless MD, Takayama S*, Reconfigurable elastic nanochannels for tunable nanofluidic manipulation, Nature Materials, 2007,6: 424-428
[20] Lam MT, Sim S, Zhu XY, Takayama S*, The effect of continuous wavy micropatterns on silicone substrates on the alignment of skeletal muscle myoblasts and myotubes. Biomaterials, 2006,27: 4340-4347
[21] Chung Y, Zhu XY, Gu W, Smith GD, Takayama S*, Microscale integrated sperm sorter. Methods in Molecular Biology, 2006,321: 227-244
[22] Suh RS, Zhu XY, Phadke N, Ohl DA, Takayama S, Smith GD*, In vitro fertilization within microfluidic channels requires lower total numbers and lower concentrations of spermatozoa. Human Reproduction, 2006,21: 477-483
[23] Zhu XY, Mills KL, Peters PR, Bahng JH, Liu E, Shim J, Naruse K, Csete ME, Thouless MD, Takayama S*, Fabrication of reconfigurable protein matrices by cracking. Nature Materials, 2005,4: 403-406 (Also featured as a Cover Article)
[24] Zhu XY, Bersano-Begey TF, Kamotani Y, Takayama S*, Microbioreactor, The Wiley Encyclopedia of Medical Instruments and Devices. 2nd ed. Wiley, 2005
[25] Zhu XY, Bersano-begey TF, Takayama S*, Nanomaterials for engineering cells, In: Nalwa HS, editor. Encyclopedia of Nanoscience and Nanotechnology, American Scientific Publisher, 2004, 857
[26] Zhu XY, Chu LY, Chueh BH, Shen MW, Hazarika B, Phadke N, Takayama S*, Arrays of horizontallyoriented mini-reservoirs generate steady microfluidic flows for continuous perfusion cell culture and gradient generation, Analyst, 2004, 129:1026-1031
[27] Gu W, Zhu XY, Futai N, Cho BS, Takayama S*, Computerized microfluidic cell culture using elastomeric channels and Braille displays, Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2004,101: 15861-15866
[28] Shim J, Bersano-Begey TF, Zhu XY, Tkaczyk AH, Linderman J, Takayama S*, Micro- and nanotechnologies for studying cellular function, Current Topics in Medicinal Chemistry, 2003,3: 687
[29] Cho BS, Schuster TG, Zhu XY, Chang D, Smith GD, Takayama S*, Passively-driven integrated microfluidic system for separation of motile sperm, Analytical Chemistry, 2003,75: 1671-1675