朱晓玥,教授,博士生导师
一、联系地址:
福建农林大学海峡联合研究院福州350002
Email: xiaoyuezhu@fafu.edu.cn
二、学习及工作经历:
2016至今 福建农林大学,教授
2013-2016 东华大学, 副教授
2006-2013 美国 Incept BioSystems, Inc.,工程师
2005-2006 美国University of Michigan - Ann Arbor,博士后
2002-2005 美国University of Michigan - Ann Arbor,博士
三、成果:
1成功建立了一套以纳米材料及微流控芯片为基础的研究细胞功能和生长发育的全新实验方法和体系
2 研制开发了一系列细胞特异性的微流控芯片及纳米材料,获得美国授权专利四项
四、研究方向:
通过研发各种新型植物及动物细胞培养平台,对园艺作物发育及代谢组产物进行功能性研究。在细胞和组织层面,通过将纳米技术及细胞生物学技术相结合的全新方法,进一步探索细胞生长和发育的分子机理。
五、发表文章:
1.Wu JC, Bai QZ, Chen JH, Yang ZB, Zhu XY*. Systemic analyses of anti-cell-senescence active compounds in Camellia Sect. Chrysantha Chang and their mechanisms. Plants, 2024, 13(15): 2139. (https://doi.org/10.3390/plants13152139)
2. Gao SY, Xu TG*, Wu L*, Zhu XY, Wang XF, Chen Y, Li G, Li XX*. Complete prevention of bubbles in PDMS-based digital PCR chip with a dual-function cavity. Biosensors, 2024, 14(3): 114 (https://doi.org/10.3390/bios14030114)
3.Gao SY, Xu TG*, Wu L*, Zhu XY, Wang XF, and Jian XH, Li XX*. Overcoming bubble formation in polydimethylsiloxane-made PCR chips: mechanism and elimination with high-pressure liquid seal. Microsystems & Nanoengineering, 2024, 10: 136 (https://doi.org/10.1038/s41378-024-00725-1)
4.Zhou X*, Han W, Dai J, Liu S, Gao S, Guo Y, Xu T, Zhu XY*. SPA, a Stigma-style-transmitting tract Physical microenvironment Assay for investigating mechano-signaling in pollen tubes, PNAS, 2023, 120(49): e2314325120 (doi:10.1073/pnas.2314325120)
5.Hao GJ, Li LS, Zhao XY, Ying J, Zhang MM, Cui XC, Sun T, Li E, Su LY, Shen J, Zhou X, Zhu XY, Li S*, Zhang Y*. Canonical Rab5 GTPases are essential for pollen tube growth through style in Arabidopsis. New Phytologist, 2023 Sep;239(5):1740-1753
6.Xu GW, Tan YL, Xu TG, Yin D, Wang MY, Shen MW, Chen XF*, Shi XY*, Zhu XY*, Hyaluronic acid-functionalized electrospun PLGA nanofibers embedded in a microfluidic chip for cancer cell capture and culture. Biomaterial Sciences, 2017. DOI:10.1039/c6bm00933f
7.Fan ZY, Zhao YL, Zhu XY*, Luo Y, Shen MW, Shi XY*, Folic acid-modified electrospun polyvinyl alcohol/polyethyleneimine nanofibers for cancer cell capture applications. Chin. J. Polym. Sci. 2016, 34, 755 - 765. doi:10.1007/s10118-016-1792-6
8.Kim SJ, Zhu XY, Takayama S*, Gravity-driven fluid pumping and cell manipulation. Book Chapter in Microtechnology for Cell Manipulation and Sorting. Springer International Publishing, 2016, 175-192. DOI: 10.1007/978-3-319-44139-9_6Editors: Wonhee Lee, Peter Tseng, and Dino Di Carlo
9.Zhou BQ, Yang J, Peng C, Zhu JZ, Tang YQ, Zhu XY, Shen MW, Zhang GX*, Shi XY*, PEGylated polyethylenimine-entrapped gold nanoparticles modified with folic acid for targeted tumor CT imaging. Colloids and Surfaces B. Biointerfaces, 2016:140:489-496. DOI: 10.1016/j.colsurfb.2016.01.019
10.Li D, Zhang YX, Wen SH, Song Y, Tang YQ, Zhu XY, Shen MW, Mignani S, Majoral JP, Zhao QH*, Shi XY *, Polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors. J. Mater. Chem. B 2016, 4, 4216 - 4226
11.Chen C, Zhou BQ, Zhu XY, Shen MW, Shi XY*, Branched polyethyleneimine modified with hyaluronic acid via a PEG spacer for targeted anticancer drug delivery. RSC Adv. 2016, 6, 9232 - 9239
12.Zhao YL, Zhu XY, Liu H, Luo Y, Wang SG, Shen MW, Zhu MF, Shi XY *, Dendrimer-functionalized electrospun cellulose acetate nanofibers for targeted cancer cell capture applications. J. Mater. Chem. B 2014, 2, 7384–7393
13.Moracs C, Kim BC, Zhu XY, Mills K, Dixon AR, Thouless MD, Takayama S*, Defined topologically-complex protein matrices to manipulate cell shape via three-dimensional fiber-like patterns, Lab-on-a-chip, DOI:10.1039/C4LC00122B, 2014
14.Mills KL, Zhu XY, Takayama S, Thouless MD*, The mechanical properties of a surfacemodified layer on poly(dimethylsiloxane), Journal of Materials Research, 2008,23: 37-48
15.Huh D, Mills KL, Zhu XY, Burns MA, Thouless MD, Takayama S*, Reconfigurable elastic nanochannels for tunable nanofluidic manipulation, Nature Materials, 2007,6: 424-428
16.Lam MT, Sim S, Zhu XY, Takayama S*, The effect of continuous wavy micropatterns on silicone substrates on the alignment of skeletal muscle myoblasts and myotubes. Biomaterials, 2006,27: 4340-4347
17.Chung Y, Zhu XY, Gu W, Smith GD, Takayama S*, Microscale integrated sperm sorter. Methods in Molecular Biology, 2006,321: 227-244
18.Suh RS, Zhu XY, Phadke N, Ohl DA, Takayama S, Smith GD*, In vitro fertilization within microfluidic channels requires lower total numbers and lower concentrations of spermatozoa. Human Reproduction, 2006,21: 477-483
19.Zhu XY, Mills KL, Peters PR, Bahng JH, Liu E, Shim J, Naruse K, Csete ME, Thouless MD, Takayama S*, Fabrication of reconfigurable protein matrices by cracking. Nature Materials, 2005,4: 403-406 (Also featured as a Cover Article)
20.Zhu XY, Bersano-Begey TF, Kamotani Y, Takayama S*, Microbioreactor, The Wiley Encyclopedia of Medical Instruments and Devices. 2nd ed. Wiley, 2005
21.Zhu XY, Bersano-begey TF, Takayama S*, Nanomaterials for engineering cells, In: Nalwa HS, editor. Encyclopedia of Nanoscience and Nanotechnology, American Scientific Publisher, 857, 2004
22.Zhu XY, Chu LY, Chueh BH, Shen MW, Hazarika B, Phadke N, Takayama S*, Arrays of horizontallyoriented mini-reservoirs generate steady microfluidic flows for continuous perfusion cell culture and gradient generation, Analyst, 2004,129:1026-1031
23.Gu W, Zhu XY, Futai N, Cho BS, Takayama S*, Computerized microfluidic cell culture using elastomeric channels and Braille displays, Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2004,101: 15861-15866
24.Shim J, Bersano-Begey TF, Zhu XY, Tkaczyk AH, Linderman J, Takayama S*, Micro- and nanotechnologies for studying cellular function, Current Topics in Medicinal Chemistry, 2003,3: 687
25.Cho BS, Schuster TG, Zhu XY, Chang D, Smith GD, Takayama S*, Passively-driven integrated microfluidic system for separation of motile sperm, Analytical Chemistry, 2003,75: 1671-1675

