吴双教授

  发布时间: 2015-01-05   信息员:   

吴双

教授

博士生导师、硕士生导师
国家“青年千人计划”学者、福建省“百人计划”学者

福建农林大学蔬菜学科带头人


迄今在国际主流学术杂志发表论文16篇,其中第一作者为10篇。目前为PNAS, Plant Cell, Plant Physiology,Plant Cell Reports,Plos One等国际期刊审稿人。多次获得美国自然科学基金和美国农业部等的研究奖励。并获得2016年福建省青年科技奖。


联系方式:
电话: (0591)86393541;
Email: wus@fafu.edu.cn

英文主页:http://fafu-ucr-hbmc.ucr.edu/shuang.html


学习及工作经历:
2015-至今 福建农林大学海峡联合研究院,教授
2009-2014 美国宾夕法尼亚大学,博士后
2003-2009 美国麻省大学,植物生物学,博士


研究兴趣:
(1)植物干细胞分裂和分化的分子学基础
(2)细胞间信号通讯调控植物发育的系统生物学研究
(3)植物根系营养吸收调控的细胞分子机制
(4)园艺作物代谢组学研究和基因工程改良



研究方向:
   不同于动物,植物不能逃避逆境。因此植物进化出对环境适应巨大的可塑性。这种可塑性部分是通过不断得形成新的器官而实现。器官发生是生命科学的核心问题之一,从一个简单的细胞形成具有复杂结构的器官需要在时间和空间上进行精确的调控。这个调控依赖于两个过程: 细胞分裂和细胞命运的决定。我们组的研究围绕这两个问题,在多个层面上进行了展开。
我们希望理解植物干细胞在特定位置上为什么具有准确分裂方向的调整,从而产生不同的细胞层来构建器官。我们也想知道不同位置上的细胞命运是如何决定的。与动物不同,植物里通常认为位置信息决定了细胞类型的确立,而位置信息的本质是什么长久以来一直不清楚。我们实验室的切入点是从细胞间信号交流的角度去探索植物器官发育中相邻细胞是如何通过“交谈”而实现各自命运的决定。在这个分子和细胞机制的基础上,我们进一步想探明植物根系是如何接收到环境的信号,通过一系列的信号传递,对自身的发育过程进行调控,从而更好的去吸收水分养分,适应不同环境条件。


发表论文:

1. Yu Q, Li P, Liang N, Wang H, Xu M, Wu S. (2017).Specifying cell fate in roots requires coordinative lineage instruction and positional reprogramming.Plant Physioldoi: 10.1104/pp.17.00814. 


2. Liu, Y., Xu, M., Liang, N., Zheng, Y., Yu, Q., Wu, S. * (2017) Symplastic communication spatially directs local 

 auxin biosynthesis to maintain root stem cell niche in Arabidopsis, Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1  616387114


3. Yang, B., Zhou, X., Xu, R., Wang, J., Lin, Y., Pang, J., Wu, S. *, Zhong, F. * (2016)  Comprehensive Analysis of Photosynthetic Characteristics and Quality Improvement of Purple Cabbage under Different Combinations of Monochromatic Light, Front Plant Sci. 29;7:1788. (*Co-corresponding author)


4. Wu, S.*, O'Lexy, R., Xu, M., Sang, Y., Chen, X., Yu, Q. & Gallagher, K.* (2016) A Symplastic signaling instructs cell division, cell expansion, and cell polarity in the ground tissue of Arabidopsis thaliana roots, Proc Natl Acad Sci U S A. pii: 201610358 (*Co-corresponding author)


5. Wu, S., Hayashi, T., Lee, C.M., Price, S., Divol, F., Henry, S., Pauluzzi, G., Perin, C. & Gallagher, K. (2014) A plausible mechanism, based upon SHORT-ROOT movement, for regulating the number of cortex cell layers in roots, Proc Natl Acad Sci U S A. 11;111(45):16184-9. 


6. Wu, S. & Gallagher, K.L. (2014) The movement of the non-cell-autonomous transcription factor, SHORT-ROOT relies on the endomembrane system, Plant J. 80(3):396-409. (Faculty of 1000)


7. Wu, S. & Gallagher, K.L. (2015) Techniques for Assessing the Effects of Pharmacological Inhibitors on Intercellular Protein Movement.  Methods in Molecular Biology.1217:245-58.


8. Wu, S.& Gallagher, K.L. (2013) Intact microtubules are required for the intercellular movement of the SHORT-ROOT transcription factor. Plant J. 74(1):148-159. (Faculty of 1000)  


9. Wu, S., Baskin, T.I. & Gallagher, K.L. (2012) Mechanical fixation techniques for processing and orienting delicate samples, such as the root of Arabidopsis thaliana, for light or electron microscopy. Nature Protocols. 7(6):1113-24.


10. Wu, S. & Gallagher, K.L. (2012) Transcription Factors on the Move. Curr Opin Plant Biol. 15(6):645-651.


11. Koizumi, K.*, Wu, S.(co-first author), MacRae-Crerar, A., Gallagher, K.L. (2011) An essential protein that interacts with endosomes and promotes movement of the SHORT-ROOT transcription factor. Current Biology. 21(18):1559-1564. (Faculty of 1000)


12. Wu, S. & Gallagher, K.L. (2011) Mobile protein signals in plant development. Curr Opin Plant Biol. 14(5):563-70


13. Wu, S.*, Koizumi, K., Macrae-Crerar, A., Gallagher, K.L. (2011) Assessing the utility of photoswitchable fluorescent proteins for tracking intercellular protein movement in the Arabidopsis root. PLoS One. 2011; 6(11):e27536. (Faculty of 1000)  (Selected by the illuminated plant cell as paper of the month, Feb 2012)


14. Wu, S., Scheible, W. R., Schindelasch, D., Van Den Daele H., De Veylder L., & Baskin, T. I. (2010) A conditional mutation in Arabidopsis thaliana separase induces chromosome non-disjunction, aberrant morphogenesis and cyclin B1;1 stability.Development.137(6):953-961. (Faculty of 1000)


15. Wu, S., Gu, Y., Zhao, L. & Liu, J. (2003) Effects of synchrotron radiation from soft X-rays on peroxidation products of membrane lipids and activity of related enzymes in wheat seeds. Nuclear Techniques. 26: 577-581.


16. Chen, X., Wu, S., Liu, Z., Friml, J. (2016) Environmental and Endogenous Control of Cortical Microtubule Orientation.Trends Cell Biol. 26(6):409-19.


17. Koizumi, K., Hayashi, T., Wu, S., Gallagher, K.L. (2012) The SHORT-ROOT protein acts as a mobile, dose-dependent signal in patterning the ground tissue. Proc Natl Acad Sci U S A. 109(32):13010-5. (Faculty of 1000)


18. Sang, Y., Silva-Ortega, C.O., Wu, S., Yamaguchi, N., Wu, M.F., Pfluger, J., Gillmor, S., Gallagher, K.L., Wagner, D. (2012) Mutations in two non-canonical Arabidopsis SWI2/SNF2 chromatin remodeling ATPases cause embryogenesis and stem cell maintenance defects. Plant J. 72(6): 1000-1014.


19.Vatén, A., Dettmer, J., Wu, S., Stierhof, Y.D., Miyashima, S., Yadav, S.R., Roberts, C.J., Campilho, A., Bulone, V., Lichtenberger, R., Lehesranta, S., Mähönen, A.P., Kim, J.Y., Jokitalo, E., Sauer, N., Scheres, B., Nakajima, K., Carlsbecker, A., Gallagher, K.L., Helariutta, Y. (2011) Callose biosynthesis regulates symplastic trafficking during root development.Developmental Cell. 21(6):1144-1155. (Faculty of 1000) 


20. Yang, X., Boateng, K.A., Yuan, L., Wu, S., Baskin, T.I., Makaroff, C.A. (2011) The radially swollen 4 separase mutation of Arabidopsis thaliana blocks chromosome disjunction and disrupts the radial microtubule system in meiocytes. PLoS One. 29;6(4):e19459.


21. Rahman, A., Takahashi, M,, Shibasaki, K., Wu, S., Inaba T., Tsurumi, S. & Baskin, T. I. (2010) Gravitropism of Arabidopsis thaliana roots requires the polarization of PIN2 toward the root tip in meristematic cortical cells. Plant Cell. 22(6):1762-76.


22. Bischoff, V., Cookson, S. J., Wu, S. & Scheible, W. R. (2009) Thaxtomin A affects CESA-complex density, expression of cell wall genes, cell wall composition, and causes ectopic lignification in Arabidopsis thaliana seedlingsJ. Exp. Bot. 60(3): 955-65.


23. Liu, J., Zhao, Y., Zhao, J., Xia, A., Jiang, L., Wu, S., Ma, L., Dong, Y. & Gu, Y. (2002) Two-photon excitation studies of hypocrellins for photodynamic therapy. J. Photochem. Photobiol. B Biol. 68: 156-164. 

实验室成员:

齐世连

        (讲师): Tomato growth regulation under stress conditions

常江

        (高级科研助理): QC specification and stem cell niche maintenance.

杨美娜

        (科研助理):

吴俊清

        (科研助理):

吴植润

        (科研助理):

李海洋

        (科研助理):

华兵

         (博士生): Regulation of tomato root growth

许梅芝

         (硕士生): cell-to-cell communication regulates ground tissue formation.

李朋雪

         (硕士生): endodermal specification and differentiation.

梁能松

         (硕士生): stem cell regulation in response to nutrient deficiency.

于巧芝

        (往届硕士生): SHR-mediated periclinal cell division


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